13 Sep Does Low-Dose Aspirin Lower Cancer Risk in Women?
Low Dose Aspirin and Cancer
(New England Journal of Medicine Journal Watch)- Taking 100mg of aspirin every other day for 10 years was associated with lower colorectal cancer risk in women, but at the expense of ore gastrointestinal bleeds and peptic ulcers.
In this observational extension of the Women’s Health Study (N=34,000), alternate-day, low-dose aspirin use for 10 years was associated with lower colorectal cancer incidence as long as eight years later: 0.3% risk with aspirin vs. 0.6% with placebo during the post-trial observation period, and 1.0% risk with aspirin vs. 1.2% with placebo during overall follow-up. In further analyses, women originally randomized to aspirin and women continued to use aspirin during the observation period had the lowest incidence of colorectal cancer.
A commentator concedes that the benefits for colorectal cancer prevention may outweigh harms in some patients but still suggests that the finding should not alter USPSTF guidelines: aspirin should only be offered for primary prevention when potential cardiovascular benefits outweigh risks of gastrointestinal bleeding.
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